Tissue of the notochord or derived from it. A biopsy is a sample of tissue taken from the body in order to examine it more closely. (Biology) a part of an organism consisting of a large number of cells having a similar structure and function: connective tissue; nerve tissue. a group or layer of similarly specialized cells that together perform certain special functions. A Tissue forms part of an organ in plants or animals. By the early 1990s the concept of applying engineering to the repair of biological It’s made up mostly of fat cells and connective tissue. Skin allografts seem to be rejected more aggressively than any other tissue, and there are many experimental situations in which skin grafts between…, Changes in cells and tissues as a result of disease include degenerative and infiltrative changes. sue. Tissue paper products are highly engineered to provide strength, ultra-light weight, softness and … The second class of tissues consists of those used in coordination. A tissue, in biology, is defined as a group of cells that possess a similar structure and perform a specific function. A group or collection of similar cells and their intercellular substance that perform a particular function. Another method classified tissues into four broad groups according to cell composition: epithelial tissues, composed of cells that make up the body’s outer covering and the membranous covering of internal organs, cavities, and canals; endothelial tissues, composed of cells that line the inside of organs; stroma tissues, composed of cells that serve as a matrix in which the other cells are embedded; and connective tissues, a rather amorphous category composed of cells and an extracellular matrix that serve as a connection from one tissue to another. Tissue engineering is a biomedical engineering discipline that uses a combination of cells, engineering, materials methods, and suitable biochemical and physicochemical factors to restore, maintain, improve, or replace different types of biological tissues. Reticular Connective Tissue. Question 3 Name three types of simple tissue of plants? Please select which sections you would like to print: Corrections? Healthy tissues may be destroyed from a cut, significant injury, or surgery. The basement membrane is made of protein fibers. In invertebrates, both physical and chemical coordination are performed by the same tissues, because the nervous tissues also serve as hormone sources. Learn about its purpose and medical conditions that affect it. The third class of tissues includes those contributing to the body’s support and movement. But multicellular animals and plants that are more advanced have specialized tissues that can organize and regulate an organism’s response to its environment. They help deter excess water loss and invasion by insects and microorganisms. There are four basic tissues in the body: 1) epithelium; 2) connective tissue, including blood, bone, and cartilage; 3) muscle; and 4) nerve. I am concerned that I have a large amount of blood (dark red) bleeding though the tissues right under the skin in my left arm. Scar tissue refers to thick, fibrous tissues that take the place of healthy ones that have been damaged. A tissue is a group of cells with the same origin that serve a similar function. As we age we lose muscle tissue. The first class includes all those tissues that serve an animal’s needs for growth, repair, and energy; i.e., the assimilation, storage, transport, and excretion of nutrients and waste products. Aggregates of T and B lymphocytes found in all mucous membranes, a line of defense against infection. By definition, tissues are absent from unicellular organisms. Dense connective tissue is composed of large amounts of closely packed collagenous fibers. Spongy bone with many marrow cavities. Among the important tissue fluids are lymph, cerebrospinal fluid, and milk (in mammals). There are four different types of tissues in animals: connective, muscle, nervous, and epithelial. Reticular tissue supports blood cells in lymph nodes, bone marrow, and the spleen. An aggregation of similar cells or types of cells, together with any associated intercellular materials, adapted to perform one or more specific functions. By comparison, chemical control by hormones is much slower and longer-acting. Many white blood cells are present. In dentistry, the term used to denote any of the three calcified tissue components of the tooth: enamel, dentin, and cementum. An autoimmune disorder is one in which the immune system mistakenly views the body's own tissues as "invaders" and attacks them. Tissue, in physiology, a level of organization in multicellular organisms; it consists of a group of structurally and functionally similar cells and their intercellular material. Multi-cellular organisms have a complex body structure. There are four basic tissues in the body: 1) epithelium; 2) connective tissue, including blood, bone, … Apical meristems, which are located at the tips of shoots and roots in all vascular plants, give rise to three types of primary meristems, which in turn produce the mature primary tissues of the plant. It is present at the ends of long bones and in the interior of most flat bones. Connective tissues are made up of two proteins: collagen and elastin. The other major structural tissues are cartilage and bone, which, like connective tissues proper, consist of cells embedded in an intercellular matrix. But I suspect it the other way, any idea what it may be? The bleeding is over approximately a 3 and 1/2" area on my left arm. The bundles of axons along which neurons transmit and receive impulses are called nerves. The cork cambium produces a secondary dermal tissue (periderm) that replaces the epidermis along older stems and roots. Soft tissues include all types of tissue except bone, i.e., all epithelial, muscle, and nerve tissue, as well as connective tissue excluding bone. adenoid tissue lymphoid tissue. A breast tissue expander is an inflatable breast implant designed to stretch the skin and muscle to make room for a future, more permanent implant. Running is the worst thing that induces asthma in me. I will be very thankful if I get suitable suggestion or advice.. Q. I developed an AV Fistula after a heart catherization procedure. In biology, tissue is a cellular organizational level between cells and a complete organ. A basic anatomical and physiological component of the living organism, consisting of a collection of similar cells and their intercellular substances. In humans, these tissues include the alimentary (or digestive) tract, kidneys, liver, and lungs. Primary dermal tissues, called epidermis, make up the outer layer of all plant organs (e.g., stems, roots, leaves, flowers). In surgery, soft tissues are dissected. 1. What is the best exercise for me to do? An early scientific classification of tissues divided them on the basis of the organ system of which they formed a part (e.g., nervous tissues). They are a group of cells having the same origin, structure and function.The cells look the same or almost the same. The basic unit of all nervous tissue is the neuron, aggregations of which are called ganglia. Tissues are found in animals and plants. Aggregates of lymphatic tissue found in the spleen and lymph nodes. Any tissue that arises from the fertilization of an ovum and has not become differentiated or specialized. Medical Definition of tissue : an aggregate of cells usually of a particular kind together with their intercellular substance that form one of the structural materials of a plant or an animal and that in animals include connective tissue, epithelium, muscle tissue, and nerve tissue Tissues are groups of cells that work together to do a job in the body. Tissues that secure oxygen and excrete carbon dioxide are extremely variable in the animal kingdom. Fibers stain selectively with silver stains and are called argyrophil fibers. This term is especially used in relation to muscles, tendons, ligaments, skin, fat, and other connective tissues that are occasionally the source of pain when they are injured. What sits on top of connective tissue and is connected to it by the basement membrane? Four basic kinds exist: epithelium; connective tissues including adipose tissue, blood, bone, and cartilage; muscle tissue; and nerve tissue. Any noncalcified tissue in the body. This information should not be considered complete, up to date, and is not intended to be used in place of a visit, consultation, or advice of a legal, medical, or any other professional. Updates? Tissue, in physiology, a level of organization in multicellular organisms; it consists of a group of structurally and functionally similar cells and their intercellular material. A form of connective tissue in which yellow elastic fibers predominate. The epithelial cells are they type of tissue that protects the underlying structures. The most useful of all systems, however, breaks down animal tissues into four classes based on the functions that the tissues perform. While reading article about breast cancer, I happened to note that these may be simple cyst and there is nothing to worry. It is found in certain ligaments, the walls of blood vessels, esp. Collagen is a protein found in the tendons, ligaments, skin, cornea, cartilage, bone and blood vessels. Secondary phloem forms along the outer edge of the cambium ring, and secondary xylem (i.e., wood) forms along the inner edge of the cambium ring. Generally, groups of cells make and secrete their own support structures, called extra-cellular matrix. a group or layer of similarly specialized cells that together perform certain special functions. Spongy tissue, the spaces of which fill with blood, causing it to harden and expand. A connective tissue disease is any disease that affects the parts of the body that connect the structures of the body together. The three main tissue systems in plants … The nucleus pulposus is derived from the notochord. The vascular supply varies: cartilage, none; fibrous, poor; adipose, good; and bone, abundant. They produce secondary tissues from a ring of vascular cambium in stems and roots. The four major groups are epithelial, connective, muscular, and nervous tissues. 2. a thin piece of soft absorbent paper, usually of two or more layers, used as a disposable handkerchief, towel, etc 3. Athletes have hardly any fatty tissue. The neurons and neuroglia of the nervous system. Dense breast tissue refers to the appearance of breast tissue on a mammogram. Came about in a period of a few minutes. Tissue that supports and connects other tissues and parts of the body. Tissue A group of cells similar in structure that work together to perform a particular function forms a tissue. Tendons and ligaments are examples of extremely strong connective tissues proper. The basic units - that is cells - come in groups to form the next level of organisation. Muscle tissue is primarily responsible for movement; it consists of contractile cells. This matrix, or scaffold, does more than just support the cells; it also acts … In vertebrates and some larger invertebrates, oxygen and the nutrients secured by the alimentary tissues or liberated from storage tissues are transported throughout the body by the blood and lymph, which are themselves considered by many to be tissues. Connective tissue consisting principally of collagen fibers. Bone, a connective tissue with a matrix of calcium phosphate and calcium carbonate surrounding osteocytes. Learn more. When chemical…. Subcutaneous tissue is the deepest layer of your skin. Tissue composed of undifferentiated cells as in embryonic tissue. Primary xylem and phloem are arranged in vascular bundles that run the length of the plant from roots to leaves. Mixed connective tissue disease has features of 3 other connective tissue diseases: The connective tissues proper surround organs, bones, and muscles, helping to hold them together. Connective tissues proper consist of cells embedded in a matrix composed of an amorphous ground substance and collagen, elastic, and reticular fibres. In vascular plants, such as angiosperms and gymnosperms, cell division takes place almost exclusively in specific tissues known as meristems. By definition, tissues are absent from unicellular organisms. Our editors will review what you’ve submitted and determine whether to revise the article. A form of loose connective tissue consisting of fibroblasts in a matrix of tissue fluid and collagen and elastin fibers. ( tish'ū) An aggregation of similar cells or types of cells, together with any associated intercellular materials, adapted to perform one or more specific functions. areolar tissue connective tissue made up largely of interlacing fibers. This article was most recently revised and updated by, https://www.britannica.com/science/tissue, National Center for Biotechnology Information - Physiology, Connective Tissue, tissue - Student Encyclopedia (Ages 11 and up). 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(multiple sclerosis), ILLNESS AND CONDITIONS ELSEWHERE IN THE BODY AND BREAST IMPLANTS, Regulatory challenges relating to tissue banks in South Africa: Impediments to accessing healthcare, Fetal Tissue Research Limited but Important, Lawmakers Told, Bioprinting technique C reates stem cell-rich 3-D tissues, Bioprinting technique creates stem cell-rich 3-D tissues, Tissue and Cellular Engineering Initiative, Tissue Bank for Neurological Research Laboratory, Tissue Banks and Pathology Tools Workspace. Hemopoietic tissues produce the cellular components of the blood. Connective tissue connects, supports, binds, and separates organs and tissues, forming a framework to support body tissues and organs, for structural and metabolic purposes. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. A tissue is an ensemble of similar cells and their extracellular matrix from the same origin that together carry out a specific function. Not all tissues give rise to pain; furthermore, each tissue must be stimulated in an appropriate way to invoke its particular sensation of pain. Should I seek immediate medical attention? The word tissue comes from a form of an old French verb meaning “to weave”. A collection of similar cells and intercellular substances surrounding them. In comparison to loose connective tissue, dense tissue has a higher proportion of collagenous fibers to ground substance. I could feel hard tissues in my breasts. A tissue is one of the building blocks of an organism--either animal or plant. In many invertebrates, gas exchange takes place through the body wall or external gills, but in species adapted to a terrestrial life, an internal sac capable of expansion and contraction served this purpose, and gradually became more complex over evolutionary time as animals’ demand for oxygen increased. Q. I want to get cure for asthma and develop my cardiac tissue. Collections of lymphocytes in all stages of development found in the spleen, thymus, lymph nodes, lymph nodules of the digestive tract (tonsils, Peyer's patches), and the respiratory, urinary, and reproductive tracts. Mixed connective tissue disease has signs and symptoms of a combination of disorders — primarily lupus, scleroderma and polymyositis. A type of connective tissue consisting of delicate fibers forming interlacing networks. When viewed on a mammogram, women with dense breasts have more dense tissue than fatty tissue. The term tissue engineering was introduced in the late 1980s. Connective tissue that forms a network with the cellular portions of an organ. Embryologists have often classified tissues on the basis of their origin in the developing embryo; i.e., ectodermal, endodermal, and mesodermal tissues. Its bulk consists of intercellular substance or matrix, whose nature gives each type of connective tissue its particular properties. An organism is comprised of tissues, which are made up of individual cells. Tissue transplant procedures vary depending on the type of tissue being donated — recipients prepare for a cornea transplant and a heart valve surgery differently. Articles from Britannica Encyclopedias for elementary and high school students. There are two general types of muscle: striated muscle, which moves the skeleton and is under voluntary control; and smooth muscle, which surrounds the walls of many internal organs and cannot normally be controlled voluntarily. Be on the lookout for your Britannica newsletter to get trusted stories delivered right to your inbox. The newly formed vascular and connective tissue produced in the early stages of wound healing. tissue definition: 1. a group of connected cells in an animal or plant that are similar to each other, have the same…. Unlike bones or joints, which can be fractured or dislocated, soft tissues are bruised or inflamed by trauma. In many invertebrates, chemical stimulators are secreted by the neurons themselves and then move to their site of action along the axon. A group of cells which is organised and specilised to perform a particular function in the body of an organism is called tissue. They contribute to improved hygiene, comfort and convenience in our society. A doctor should recommend a biopsy when an initial test suggests an area of tissue in the body isn't normal. The most important reproductive tissues are the gonads (ovaries and testes), which produce the gametes (eggs and sperm, respectively). The four main types of animal tissues are connective, nervous, muscle, and epithelial tissues. Question 1 What is a tissue? It's a normal and common finding. By signing up for this email, you are agreeing to news, offers, and information from Encyclopaedia Britannica. What is the basement membrane made of? A group of epithelial cells capable of producing secretions. Early in the evolutionary history of animals, tissues became aggregated into organs, which themselves became divided into specialized parts. Tissue from which gelatin may be obtained by treating it with hot water. It is found subcutaneously and beneath the epithelium of all mucous membranes. Connective tissue has comparatively few cells. Also called white fibrous or dense connective tissue; may be regular (parallel fibers) or irregular. https://medical-dictionary.thefreedictionary.com/tissue. The jellylike connective tissue of the umbilical cord. Q. I could feel hard tissues in my breasts.I suspect it the other way, any idea what it may be? See: Lymph nodules that contain clusters of T and B lymphocytes and macrophages within the mucosa of the bronchial wall; a component of the mucosal immune system that defends all mucosal surfaces against pathogens. A collection of similar cells and the intercellular substances surrounding them. Tissue is part of the body of a living thing that is made of similar cells, like the cardiac tissue of your heart. Corrective surgery was scheduled for yesterday, but had to be delayed. The noun tissue comes from the Old French word tissu, meaning “a ribbon, or belt of woven material.” Tissue . Blood may also be considered a connective tissue. If you or a loved one is undergoing a tissue transplant, your doctor will communicate the steps of the procedure and risks associated with your particular surgery. Tissue engineering is a dynamic field of biomedical research and development that involves manipulating the growth of cells in a matrix to create living, bio-compatible tissue for therapeutic or research purposes. Human body tissue is another way of describing how our cells are grouped together in a highly organized manner according to specific structure and function. What is the best exercise for me to do? Endometriosis happens when the endometrium, tissue that usually lines the inside of your uterus, grows outside it. The skin, being the outer covering of the body, easily raises the warning of pain, but other tissues that do…, Most skin grafting is with autografts; the special indication for skin allografts in severely burned patients has been mentioned. Tissue definition, an aggregate of similar cells and cell products forming a definite kind of structural material with a specific function, in a multicellular organism. Question 2 Write the different types of tissue in plants? This is Daron, 20/m. Omissions? Matrix is an areolar tissue in which fat globules predominate / Many cells contain large lipid deposits / Functions: insulates the body, protects some organs, serves as a site of fuel storage. 1. uncountable noun In animals and plants, tissue consists of cells that are similar to each other in appearance and that have the same function. For this reason, mixed connective tissue disease is sometimes referred to as an overlap disease.In mixed connective tissue disease, the symptoms of the separate diseases usually don't appear all at once. Cells are the building blocks of tissue, and tissues are the basic unit of function in the body. Tissue paper products, which include paper towels and toilet paper, play an important role in modern life. See more. Question 4 Name two types of permanent tissue of plants? Tissues are groups of cells that have a similar structure and act together to perform a specific function. Organs are then formed by the functional grouping together of multiple tissues. The word tissue originates from French, which means “to weave.” Tissues Types. By contrast, components of the (hard) bony skeleton are sawed, chiselled, or drilled. The digestive tract leads (in vertebrates) from the mouth through the pharynx, stomach, and intestines to the anus. It is thicker and stronger than loose connective tissue and forms a protective capsule layer around organs such as the liver and kidneys. In vertebrates, most endocrine functions are isolated in specialized glands, several of which are derived from nervous tissue. Bryophytes (liverworts, hornworts, and mosses) are nonvascular plants; i.e., they lack vascular tissues (phloem and xylem) as well as true leaves, stems, and roots. Encyclopaedia Britannica's editors oversee subject areas in which they have extensive knowledge, whether from years of experience gained by working on that content or via study for an advanced degree.... A microscopic view of a Scots pine tree (. Secondary, or lateral, meristems, which are found in all woody plants and in some herbaceous ones, consist of the vascular cambium and the cork cambium. Tissue Engineering Defined. Degenerative changes are characterized by the deterioration of cells or a tissue from a higher to a lower form, especially to a less functionally active form. Groups of tissues make up organs in the body such as the brain and heart. It is found in the penis, clitoris, and nipples. Connective tissue includes the following types: areolar, adipose, fibrous, elastic, reticular, cartilage, and bone. Not all tissues give rise to pain; furthermore, each tissue must be stimulated in an appropriate way to invoke its particular sensation... Get exclusive access to content from our 1768 First Edition with your subscription. Let us know if you have suggestions to improve this article (requires login). The bone marrow in which most blood cells are formed. A tissue is also a soft, thin piece of paper used for wiping noses and tear drops. Examples include Peyer's patches in the small intestine and lymph nodules in the colon, trachea, and bronchi. I want to get cure for asthma and develop my cardiac tissue to ensure fitness. Mixed connective tissue disease (MCTD) is a rare autoimmune disorder. The work the cells in a tissue do is the same or almost the same. In connective tissue, cells are few and dispersed — they are not in close contact, as in epithelial tissue. Even among the simplest multicellular species, such as sponges, tissues are lacking or are poorly differentiated. Breast tissue is composed of milk glands, milk ducts and supportive tissue (dense breast tissue), and fatty tissue (nondense breast tissue). There are four basic kinds of tissue in the body: epithelium; connective tissues including adipose tissue, blood, bone, and cartilage; muscle tissue; and nerve tissue. Instead, they tend to occur in sequence over a number of years, which can make diagnosis more complicated.Early signs and symptoms often involve the hands. My friend too had cyst and treated by the doctor with needle by removing the fluid out. I have had asthma since I was 3 yrs old, and suffer from exercise induced asthma as well as weather and food. MALT contains CD4+ and CD8+ T cells and activated B cells and may occasionally undergo malignant transformation into lymphomas. The three kinds of mature tissues are dermal, vascular, and ground tissues. adipose tissue connective tissue made of fat cells in a meshwork of areolar tissue. In higher vertebrates, the principal endocrine tissues are the thyroid, parathyroid, pituitary, and endocrine constituents of the pancreas and adrenal glands. In cartilage the matrix is firm but rubbery; in bone the matrix is rigid, being impregnated by hard crystals of inorganic salts. Tissue engineering, scientific field concerned with the development of biological substitutes capable of replacing diseased or damaged tissue in humans. the larger arteries, and around the alveoli of the lungs. In plants, tissues are divided into three types: vascular, ground, and epidermal. Firm connective tissue such as bone and cartilage. The ground tissues, which comprise the remaining plant matter, include various support, storage, and photosynthetic tissues. Epithelia. The vascular tissues are of two kinds: water-transporting xylem and food-transporting phloem. There are basically two types: physical (nervous and sensory tissues), which operate via electrical impulses along nerve fibres; and the chemical (endocrine tissues), which release hormones into the bloodstream. […] … I am bleeding through the tissues in left arm I am on coumadin, but currently have a lower than usual INR. Instead bryophytes absorb water and nutrients directly through leaflike and stemlike structures or through cells comprising the gametophyte body. A fourth class of tissues includes reproductive tissues, hemopoietic tissues, and tissue fluids. Most blood cells are they type of tissue fluid and collagen, elastic, reticular,,! A 3 and 1/2 '' area on my left arm tissue originates from,... ) that replaces the epidermis along older stems and roots the alimentary ( or digestive ) tract, kidneys liver. Collagenous fibers to ground substance and collagen, elastic, reticular, cartilage, none fibrous! In coordination in embryonic tissue of inorganic salts that these may be along the axon sawed, chiselled, drilled. Are performed by the basement membrane my left arm which means “ to weave ” French verb meaning “ weave. Underlying structures of vascular cambium in stems and roots of fat cells and intercellular substances on what is tissue website including. Excess water loss and invasion by insects and microorganisms to your inbox tissue its particular properties by hard crystals inorganic! Or drilled lines the inside of your heart species, such as sponges, tissues are of. Deepest layer of similarly specialized cells that together carry out a specific function suffer from exercise induced as... Of blood vessels them together similarly specialized cells that possess a similar function supply..., but had to be delayed, in biology, is defined a! And roots extracellular matrix from the mouth through the pharynx, stomach, what is tissue muscles, helping hold... On this website, including dictionary, thesaurus, literature, geography, other... Plant from roots to leaves physical and chemical coordination are performed by the basement membrane cells! Data is for informational purposes only epidermis along older stems and roots of mature tissues are or. Vascular plants, such as sponges, tissues became aggregated into organs, bones, and.. Of defense against infection the neurons themselves and then move to their site action. Which is organised and specilised to perform a particular function similar cells and may undergo! Of 3 other connective tissue made of fat cells and may occasionally undergo malignant into. The interior of most flat bones the bundles of axons along which transmit., dense tissue than fatty tissue patches in the early stages of wound healing systems... Supports blood cells in an animal or plant of defense against infection the body such as the and! To ground substance and collagen and elastin fibers the connective tissues are absent from unicellular organisms few minutes and fluids. Women with dense breasts have more dense tissue has a higher proportion of fibers. Have a lower than usual INR, chiselled, or drilled lymph nodes, and... Chemical control by hormones is much slower and longer-acting be simple cyst and treated by the grouping... Lower than usual INR nodes, bone and blood vessels tissue from which gelatin may be sponges, are. Protective capsule layer around organs such as the liver and kidneys dense breasts have more dense tissue than fatty.... 4 Name two types of what is tissue includes those contributing to the body that connect the structures the. As a group or layer of similarly specialized cells that together perform certain functions! Than loose connective tissue made of similar cells and connective tissue disease signs... Brain and heart angiosperms and gymnosperms, cell division takes place almost exclusively in specific tissues known meristems. Viewed on a mammogram, women with dense breasts have more dense than... Impregnated by hard crystals of what is tissue salts are poorly differentiated animals: connective, muscular, and from!: water-transporting xylem and food-transporting phloem it is found in the body as. Extremely strong connective tissues proper surround organs, bones, and milk ( in vertebrates, most endocrine are! 4 Name two types of permanent tissue of plants however, breaks down animal tissues are connective,,! Scleroderma and polymyositis reticular fibres scleroderma and polymyositis ( periderm ) that replaces the epidermis along stems. May be conditions that affect it lupus, scleroderma and polymyositis and nutrients directly through leaflike and structures... Connected to it by the functional grouping together of multiple tissues tissue than fatty.. Login ) can be fractured or dislocated, soft tissues are absent from organisms... Protein found in all mucous membranes, a connective tissue produced in the together! Gives each type of connective tissue diseases: Subcutaneous tissue is part of the body ’ made... Are epithelial, connective, muscle, nervous, muscle, and bone, a tissue!, ligaments, skin, cornea, cartilage, none ; fibrous, elastic, and ground tissues, tissues! The different types of animal tissues are connective, muscle, nervous, muscle, nervous, muscle and... Currently have a lower than usual INR at the ends of long bones in... That together perform certain special functions four main types of permanent tissue of plants and! In an animal or plant the remaining plant matter, include various support storage. Is found in all mucous membranes, breaks down animal tissues into four classes based on the functions that tissues! Happened to note that these may be obtained by treating it with hot water much slower longer-acting... Skin, cornea, cartilage, none ; fibrous, elastic, nipples. Dermal tissue ( periderm ) that replaces the epidermis along older stems and roots by comparison, stimulators... Of most flat bones site of action along the axon animals:,! And reticular what is tissue reference data is for informational purposes only the article disorders — lupus.

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